Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution

ABSTRACT Background The endoplasmic reticulum (ER) serves as a crucial hub for protein synthesis and processing, playing an essential role in maintaining protein homeostasis. Perturbations, such as hypoxia, oxidative stress, inadequate amino acid supply, Ca2+ imbalance, and acidosis, can disrupt cel...

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Bibliographic Details

Published in:	Cancer Medicine
Main Authors:	Chaosheng Peng, Juan Wang, Shu Wang, Yan Zhao, Haoyuan Wang, Yuhao Wang, Yuxuan Ma, Jianjun Yang
Format:	Article
Language:	English
Published:	Wiley 2025-03-01
Subjects:	endoplasmic reticulum stress tumor microenvironment unfolded protein response
Online Access:	https://doi.org/10.1002/cam4.70684