ERK1-mediated GLYCTK2 phosphorylation promotes fructolysis to sustain glioblastoma survival under glucose deprivation

Abstract Metabolic plasticity sustains glioblastoma (GBM) survival under nutrient stress, yet how fructolytic adaptation compensates for glucose deprivation remains unclear. Here, we identify glycerate kinase 2 (GLYCTK2) as a glucose-sensing metabolic checkpoint that maintains GBM cell viability thr...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Yingping Li, Fenna Zhang, Fumin Hu, Rui Tong, Yueqi Wen, Guokai Fu, Xueli Bian
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-06-01
Online Access:	https://doi.org/10.1038/s41420-025-02544-3