The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in Cell Models of Huntington’s Disease

Huntington’s disease (HD) is a monogenetic neurodegenerative disorder characterized by the accumulation of polyglutamine-expanded huntingtin (mHTT). There is currently no cure, and therefore disease-slowing remedies are sought to alleviate symptoms of the multifaceted disorder. Encouraging findings...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Elisabeth Singer, Lilit Hunanyan, Magda M. Melkonyan, Jonasz J. Weber, Lusine Danielyan, Huu Phuc Nguyen
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Subjects:	Huntington’s disease huntingtin neurodegeneration alpha-2 adrenoceptor beditin autophagy
Online Access:	https://www.mdpi.com/1424-8247/14/3/257