Myeloid p38α signaling promotes intestinal IGF‐1 production and inflammation‐associated tumorigenesis

Abstract The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis‐induced tumorigenesis. However, little is known on the contribution of p38α signaling in intestinal stromal cells. Here, we show that myeloid cell‐specifi...

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Bibliographic Details
Published in:EMBO Molecular Medicine
Main Authors: Catrin Youssif, Monica Cubillos‐Rojas, Mònica Comalada, Elisabeth Llonch, Cristian Perna, Nabil Djouder, Angel R Nebreda
Format: Article
Language:English
Published: Springer Nature 2018-06-01
Subjects:
colon tumorigenesis
IGF‐1
intestinal inflammation
macrophage
p38 MAPK
Online Access:https://doi.org/10.15252/emmm.201708403

Internet

https://doi.org/10.15252/emmm.201708403

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