Blocking PERK resuces vascular smooth muscle cells from homocysteine-induced ER stress and apoptosis

Hyperhomocysteinemia induces stress response in endoplasmic reticulum (ERS). Here, we tested whether blockage of homocysteine (Hcy) induced ERS and subsequent apoptosis in vascular smooth muscle cells can be inhibited by blockage of PERK/eIF2α/ATF4/CHOP signaling. Short-term exposure of vascular smo...

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發表在:	Frontiers in Bioscience-Landmark
Main Authors:	Wei Li, Fujun Shang, Xiaoli Li, Shaoping Lu, Xiaolin Niu, Zhimin Zhang, Jing Liu, Xue Li, Lianyou Zhao
格式:	Article
語言:	英语
出版:	IMR Press 2020-01-01
主題:	homocysteine vsmcs salubrinal endoplasmic reticulum stress apoptosis
在線閱讀:	https://www.imrpress.com/journal/FBL/25/3/10.2741/4819