Delivery of a novel membrane-anchored Fc chimera enhances NK cell-mediated killing of tumor cells and persistently virus-infected cells.

Antibody-dependent cellular cytotoxicity (ADCC) is one of the most powerful mechanisms for Natural Killer (NK) cells to kill cancer cells or virus-infected cells. A novel chimeric protein (NA-Fc) was created, which when expressed in cells, positions an IgG Fc domain on the plasma membrane, mimicking...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Namita Varudkar, Elisabeth M Shiffer, Jeremiah L Oyer, Alicja Copik, Griffith D Parks
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0285532