The potential impact of GLS and PDHA1 on tumor immunity and immunotherapy response in LUSC

BackgroundLung squamous cell carcinoma (LUSC), a therapeutically challenging non-small cell lung cancer (NSCLC) subtype with a poor prognosis, exhibits heterogeneous responses to immunotherapy. Cuproptosis, a recently discovered regulated cell death pathway, has been hypothesised to modulate the tum...

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Bibliographic Details
Published in:Frontiers in Genetics
Main Authors: Tianhe Ling, Jiahui Wu, Ling Xiaohao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-09-01
Subjects:
lung squamous cell carcinoma (LUSC)
cuproptosis
GLS
PDHA1
immune microenvironment
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1606111/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2025.1606111/full

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