Striosome-matrix pathology and motor deficits in the YAC128 mouse model of Huntington's disease

Huntington's disease is characterized by striatal degeneration and progressive motor deficits. To examine striatal compartment-specific pathology and its relation to motor symptoms, we used immunohistochemistry to identify and measure the striosomes and matrix of 7–13-month-old YAC128 and wild...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Collene Lawhorn, Diane M. Smith, Lucy L. Brown
Format:	Article
Language:	English
Published:	Elsevier 2008-12-01
Subjects:	Basal ganglia Striatum Behavior Movement disorder
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996108001964