Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems

Hot melt extrusion (HME), a continuous manufacturing process for generating supersaturating amorphous self-micellizing solid dispersion systems (saSMSDs), holds promise for achieving amorphization of many pharmaceutical formulations. For saSMSDs generation, HME-triggered continuous processes offer a...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Huan Yu, Yanfei Zhang, Yinghui Ma, Huifeng Zhang, Chengyi Hao, Yong Zhang, Zhengqiang Li, Xianrong Qi, Nianqiu Shi
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Subjects:	hot melt extrusion (HME)-triggered amorphization continuous manufacturing process supersaturating amorphous self-micellizing solid dispersions (saSMSDs) extended supersaturable immediate release “spring-parachute” processes crystallization inhibition and stabilization of amorphism
Online Access:	https://www.mdpi.com/1999-4923/14/4/765