Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER

Cutaneous melanoma (CM) is the most aggressive and fatal malignancy among other skin cancers and its incidence has risen steadily recently around the world. Hormone-related therapy, particularly estrogen (E2) has been used as a prospective strategy for CM treatment. Quercetin and luteolin are flavon...

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Bibliographic Details

Published in:	Life
Main Authors:	Shaymaa A. Hussein, Nidaa A. Ababneh, Noor Tarawneh, Mohammad A. Ismail, Abdalla Awidi, Shtaywy Abdalla
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Subjects:	cutaneous melanoma G-protein coupled estrogen receptor GPER agonist GPER antagonist luteolin quercetin
Online Access:	https://www.mdpi.com/2075-1729/15/3/417