Synthesis and Evaluation of Colchicine C-Cyclic AmineDerivatives as Potent Anti-Biofilms Agents AgainstMethicillin-Resistant <i>Staphylococcus aureus</i>

Background/Objectives: The elimination of bacterial biofilm formation is an effective strategy against bacterial infections. The objective was to design 27 colchicine C-ring modified amine derivatives and evaluate their inhibitory activities against the biofilms of MRSA USA300. Methods: Design 27 co...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Yuxin Yang, Xin Liu, Can Sun, Yuan Fang, Danyang Qu, Zhengbin Tang, Zetao Sun, Xiaoping Zhou, Dacheng Wang
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Subjects:	MRSA anti-biofilms agents <i>icaA</i> <i>agrA</i> colchicine derivatives
Online Access:	https://www.mdpi.com/2079-6382/14/2/173