Structural basis for IL-33 recognition and its antagonism by the helminth effector protein HpARI2

Abstract IL-33 plays a significant role in inflammation, allergy, and host defence against parasitic helminths. The model gastrointestinal nematode Heligmosomoides polygyrus bakeri secretes the Alarmin Release Inhibitor HpARI2, an effector protein that suppresses protective immune responses and asth...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Abhishek Jamwal, Florent Colomb, Henry J. McSorley, Matthew K. Higgins
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Online Access:	https://doi.org/10.1038/s41467-024-49550-0