Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system

Abstract The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fr...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Su-Min Bak, Seng-Min Back, Da Yeon Kim, Soyoung Jung, Na-Young Jeung, Nan-Young Kim, Kang-Hyun Han, Yong-Bum Kim, Byoung-Seok Lee, Jun Hong Park, Hee Jun Cho, Hee Gu Lee, Ozkan Ozden, Sang Kyum Kim, Seong-Hoon Park
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Subjects:	Polygoni Multiflori Radix Genotoxicity Ames test Aroclor 1254-induced rat liver S9 Human liver S9 Metabolic activation system
Online Access:	https://doi.org/10.1038/s41598-024-72283-5