Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders

Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their inhibitory potential against monoamine oxidases (MAOs) and β-secretase (BACE-1). Six compounds inhibited MAO-B more effectively than MAO-A, and the...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Payyalot Koyiparambath Vishal, Jong Min Oh, Ahmed Khames, Mohamed A. Abdelgawad, Aathira Sujathan Nair, Lekshmi R. Nath, Nicola Gambacorta, Fulvio Ciriaco, Orazio Nicolotti, Hoon Kim, Bijo Mathew
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	monoamine oxidase β-secretase chalcones reversibility cytotoxicity molecular docking
Online Access:	https://www.mdpi.com/1999-4923/13/6/850