A Non-Canonical Role for the Glycosyltransferase Enzyme UGT2B17 as a Novel Constituent of the B Cell Receptor Signalosome

In chronic lymphocytic leukemia (CLL), an elevated glycosyltransferase UGT2B17 expression (UGT2B17<sup>HI</sup>) identifies a subgroup of patients with shorter survival and poor drug response. We uncovered a mechanism, possibly independent of its enzymatic function, characterized by an e...

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Bibliographic Details
Published in:Cells
Main Authors: Antoine Wagner, Michèle Rouleau, Lyne Villeneuve, Trang Le, Cheryl Peltier, Éric P. Allain, Caroline Beaudoin, Sophie Tremblay, Fréderic Courtier, Flora Nguyen Van Long, Isabelle Laverdière, Éric Lévesque, Versha Banerji, Katrina Vanura, Chantal Guillemette
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Subjects:
glycosyltransferase
UGT2B17
CLL
B cell receptor
BTK
ZAP70
Online Access:https://www.mdpi.com/2073-4409/12/9/1295

Internet

https://www.mdpi.com/2073-4409/12/9/1295

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