Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression

Abstract Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic alterations, including the Warburg effect and glutaminolysis, sustained in vitro by the enzyme asparagine synthetase (ASNS). Here, we used...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Sara Clerici, Christine Podrini, Davide Stefanoni, Gianfranco Distefano, Laura Cassina, Maria Elena Steidl, Laura Tronci, Tamara Canu, Marco Chiaravalli, Daniel Spies, Thomas A Bell, Ana SH Costa, Antonio Esposito, Angelo D’Alessandro, Christian Frezza, Angela Bachi, Alessandra Boletta
Format:	Article
Language:	English
Published:	Springer Nature 2024-04-01
Subjects:	ADPKD Glutamine Metabolism Metabolic Reprogramming Antisense Oligonucleotides Glycolysis
Online Access:	https://doi.org/10.1038/s44321-024-00071-9