Structural and Biological Characterizations of Novel High-Affinity Fluorescent Probes with Overlapped and Distinctive Binding Regions on CXCR4

CXC-type chemokine receptor 4 (CXCR4) is well known as a co-receptor for cellular entry and infection of human immunodeficiency virus type 1 (HIV-1). As an important member of the G protein-coupled receptor (GPCR) family, CXCR4 also mediates a variety of cellular processes and functions, such as cel...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Siyu Zhu, Qian Meng, Robert T. Schooley, Jing An, Yan Xu, Ziwei Huang
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Subjects:	CXC-type chemokine receptor 4 (CXCR4) HIV-1 infection cancer metastasis fluorescent peptidic probes distinct subpockets competitive ligand binding molecular docking simulations
Online Access:	https://www.mdpi.com/1420-3049/24/16/2928