Investigating the causal relationship and potential shared diagnostic genes between primary biliary cholangitis and systemic lupus erythematosus using bidirectional Mendelian randomization and transcriptomic analyses

BackgroundThe co-occurrence of primary biliary cholangitis (PBC) and systemic lupus erythematosus (SLE) has been consistently reported in observational studies. Nevertheless, the underlying causal correlation between these two conditions still needs to be established.MethodsWe performed a bidirectio...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Tian Tao, Anqi Tang, Lizeyu Lv, Jianhua Yuan, Ling Wu, Liangbin Zhao, Jun Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	systemic lupus erythematosus primary biliary cholangitis Mendelian randomization transcriptomic data causal relationship
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1270401/full