Lymphodepletion – an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle

Lymphodepletion (LD) or conditioning is an essential step in the application of currently used autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies as it maximizes engraftment, efficacy and long-term survival of CAR-T. Its main modes of action are the depletion and modulation...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Benno Lickefett, Lulu Chu, Valentin Ortiz-Maldonado, Linda Warmuth, Pere Barba, Matteo Doglio, David Henderson, Michael Hudecek, Andreas Kremer, Janet Markman, Magdalena Nauerth, Helene Negre, Carmen Sanges, Philipp B. Staber, Rebecca Tanzi, Julio Delgado, Dirk H. Busch, Jürgen Kuball, Maik Luu, Ulrich Jäger
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Subjects:	CAR-T cells lymphodepletion conditioning optimization efficacy toxicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303935/full