Intradermally injected abobotulinumtoxinA administered preemptively before surgery alleviates post-surgical pain and normalizes behavior in a translational animal model

Abstract Previously, abobotulinumtoxinA (aboBoNT-A) injected intraoperatively resulted in effective, but delayed post-surgical analgesia in pigs. Here, we explore the efficacy of preemptively administered aboBoNT-A in intact animals on pain and associated behaviors following a full-skin-muscle incis...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mikhail Kalinichev, Sylvie Cornet, David Castel, Sigal Meilin, Ron Horne, Laurent Pons, Stephen M. Evans, Stephane Lezmi
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Subjects:	Botulinum neurotoxin Postsurgical pain Juvenile pigs Anxiety Depression
Online Access:	https://doi.org/10.1038/s41598-025-90886-4