Licochalcone A suppresses pancreatic ductal adenocarcinoma progression by targeting eEF2K-mediated pyroptosis

Pancreatic ductal adenocarcinoma (PDAC), a highly aggressive malignancy with increasing incidence and low survival rates, urgently requires novel therapeutic strategies to overcome the limitations posed by current treatment agents like gemcitabine. Licochalcone A (LHA), a bioactive flavonoid derived...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Junjie Peng, Hiutung Chan, Wenqing Chen, Ken Kin-Lam Yung, King-Ho Cheung, Zhu Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	pancreatic ductal adenocarcinoma licochalcone A pyroptosis autophagy eEF2K
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1595686/full