Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV.

The nucleoside analogue Ribavirin significantly increases patient response to IFN-α treatment of HCV, by directly inhibiting viral replication. Recent studies indicate that Ribavirin also regulates immunity and we propose that Ribavirin enhances specific interferon sensitive gene (ISG) expression by...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Nigel J Stevenson, Alison G Murphy, Nollaig M Bourke, Catherine A Keogh, John E Hegarty, Cliona O'Farrelly
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	http://europepmc.org/articles/PMC3218071?pdf=render