Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder

We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of ado...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	D. Iezzi, L. Curti, G. Ranieri, E. Gerace, A. Costa, A. Ilari, A. La Rocca, C. Luceri, M. D’Ambrosio, L. Silvestri, M. Scardigli, G. Mannaioni, A. Masi
Format:	Article
Language:	English
Published:	Elsevier 2022-09-01
Subjects:	Autism Valproic acid Rapamycin mTOR Patch clamp Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661822003462