SNP calling, genotype calling, and sample allele frequency estimation from New-Generation Sequencing data.

We present a statistical framework for estimation and application of sample allele frequency spectra from New-Generation Sequencing (NGS) data. In this method, we first estimate the allele frequency spectrum using maximum likelihood. In contrast to previous methods, the likelihood function is calcul...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Rasmus Nielsen, Thorfinn Korneliussen, Anders Albrechtsen, Yingrui Li, Jun Wang
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3404070?pdf=render