NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury

In acute lung injury (ALI), the NF-κB-mediated downregulation of Sox18 gene expression leads to the disruption of the pulmonary endothelial barrier. Previous studies have suggested that the action of NF-κB as a transcriptional repressor also requires the action of class I histone deacetylases (HDACs...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Evgeny A. Zemskov, Christine M. Gross, Saurabh Aggarwal, Marina A. Zemskova, Xiaomin Wu, Chenxin Gu, Ting Wang, Haiyang Tang, Stephen M. Black
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	transcriptional repression histone deacetylases acute lung injury sepsis epigenetics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2022.947537/full