TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circul...

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Bibliographic Details

Published in:	eLife
Main Authors:	Marta Gawrys-Kopczynska, Marek Konop, Klaudia Maksymiuk, Katarzyna Kraszewska, Ladislav Derzsi, Krzysztof Sozanski, Robert Holyst, Marta Pilz, Emilia Samborowska, Leszek Dobrowolski, Kinga Jaworska, Izabella Mogilnicka, Marcin Ufnal
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-06-01
Subjects:	heart failure trimethylamine N-oxide seafood gut bacteria cardiovascular system
Online Access:	https://elifesciences.org/articles/57028