Human colon stem cells are the predominant epithelial responders to bacterial antigens

Intestinal epithelial cells (IECs) are capable of mounting an adequate antimicrobial inflammatory response to pathogens while tolerating commensals. The underlying regulatory mechanisms of immune sensitivity remain incompletely understood, particularly in the context of human IECs. To enhance our un...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Maaike H. De Vries, Claartje A. Meddens, Hemme J. Hijma, Anne-Claire Berrens, Suze A. Jansen, Berend A. P. Kooiman, Scott Snapper, Hans Clevers, Michal Mokry, Ewart W. Kuijk, Edward E. S. Nieuwenhuis
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	intestinal stem cells intestinal epithelium innate immunity immune regulation WNT pathway inflammatory bowel disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1677943/full