Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

During gene therapy trials, immune responses against adeno-associated virus (AAV) vectors are monitored by antibody assays that detect the humoral and T-cell mediated cellular responses to AAV vectors. T cell assays commonly utilize the collection of patients’ peripheral blood mononuclear cells (PBM...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	So Jin Bing, Stephanee Warrington, Ronit Mazor
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	adeno-associated virus vector deamidation post-translational modification crossreactivity immune monitoring
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211529/full