Exploring cell death mechanisms in spheroid cultures using a novel application of the RIP3-caspase3-assay

Abstract This study explores the application of the RIP3-caspase3-assay in heterogeneous spheroid cultures to analyze cell death pathways, emphasizing the nuanced roles of apoptosis and necroptosis. By employing directly conjugated monoclonal antibodies, we provide detailed insights into the complex...

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出版年:	Scientific Reports
主要な著者:	C. I. Philippi, J. Hagens, K. M. Heuer, H. C. Schmidt, P. Schuppert, L. Pagerols Raluy, M. Trochimiuk, Z. Li, M. J. Bunders, K. Reinshagen, C. Tomuschat
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2024-07-01
主題:	Organoids Cell death mechanisms RIP3-caspase3 assay TNFα -induced stress Apoptosis and necroptosis
オンライン･アクセス:	https://doi.org/10.1038/s41598-024-66805-4