The Class A β-Lactamase Produced by <i>Burkholderia</i> Species Compromises the Potency of Tebipenem against a Panel of Isolates from the United States

Tebipenem-pivoxil hydrobromide, an orally bioavailable carbapenem, is currently in clinical development for the treatment of extended-spectrum β-lactamase- and AmpC-producing Enterobacterales. Previously, tebipenem was found to possess antimicrobial activity against the biothreat pathogens, <i>...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Krisztina M. Papp-Wallace
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Subjects:	β-lactamase <i>Burkholderia</i> β-lactam PenA carbapenemase tebipenem
Online Access:	https://www.mdpi.com/2079-6382/11/5/674