A novel MIR100HG transcript enhances tumorigenesis by inducing BCLAF1-mediated alternative splicing in colorectal cancer

Abstract Background Long non-coding RNAs (lncRNAs) play crucial roles in cancer pathogenesis, including colorectal cancer (CRC). Distinct lncRNA transcripts from the same gene show diverse regulatory roles in cancer. The MIR100HG, a lncRNA gene characterized by multiple transcript variants, has been...

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Bibliographic Details
Published in:Cell Communication and Signaling
Main Authors: Mingrui Dai, Yuhua Shi, Hailin Zhao, Yue Hu, Xianling Cong, Bin Yu, Haihong Zhang, Xianghui Yu, Hui Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Subjects:
Colorectal cancer
LncRNA
MIR100HG
Transcript
Tumorigenesis
BCLAF1
Online Access:https://doi.org/10.1186/s12964-025-02280-2

Internet

https://doi.org/10.1186/s12964-025-02280-2

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