Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment

Background: Hepatic platelet accumulation contributes to acetaminophen (APAP)-induced liver injury (AILI). However, little is known about the molecular pathways involved in platelet recruitment to the liver and whether targeting such pathways could attenuate AILI. Methods: Mice were fasted overnight...

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Bibliographic Details

Published in:	eLife
Main Authors:	Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A Elias, William M Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-06-01
Subjects:	drug-induced liver injury platelets kupffer cells chi3l1 acetaminophen
Online Access:	https://elifesciences.org/articles/68571