Qingluo Tongbi Formula Alleviates Hepatotoxicity Induced by Tripterygium wilfordii Hook. F. by Regulating Excessive Mitophagy Through the PERK-ATF4 Pathway

Qingluo Tongbi Formula (QTF) is an empirical formula of Chinese medicine master Zhongying Zhou for the treatment of rheumatoid arthritis. Although including Tripterygium wilfordii Hook. F. (TW), it has not shown liver toxicity in clinical application for many years. Our previous studies have shown t...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Linluo Zhang, Jie Zhou, Zhe Feng, Baoping Jiang, Changqing Li, Lingling Zhou, Xueping Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Subjects:	Tripterygium wilfordii hook. f. hepatotoxicity qingluo tongbi formula mitophagy ERS PERK
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.918466/full