Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway

Abstract Background After spinal cord injury (SCI), glial scarring is mainly formed around the lesion and inhibits axon regeneration. Recently, we reported that anti-β1 integrin antibody (β1Ab) had a therapeutic effect on astrocytes by preventing the induction of glial scar formation. However, the c...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Shingo Yoshizaki, Tetsuya Tamaru, Masamitsu Hara, Ken Kijima, Masatake Tanaka, Dai-jiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada
Format:	Article
Language:	English
Published:	BMC 2021-01-01
Subjects:	Spinal cord injury Glial scar Reactive astrocyte Microglia Fibronectin
Online Access:	https://doi.org/10.1186/s12974-020-02059-x