Protective roles of thrombomodulin in cisplatin-induced nephrotoxicity through the inhibition of oxidative and endoplasmic reticulum stress

Abstract Cisplatin is an effective chemotherapeutic agent widely used for the treatment of various solid tumors. However, cisplatin has an important limitation in its use; currently, there is no method to ameliorate cisplatin-induced acute kidney injury (AKI). Thrombomodulin (TM) is well known not o...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Hiroki Yamamoto, Yuko Ishida, Siying Zhang, Miyu Osako, Mizuho Nosaka, Yumi Kuninaka, Akiko Ishigami, Yuya Iwahashi, Miki Aragane, Lennon Matsumoto, Akihiko Kimura, Toshikazu Kondo
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Subjects:	Cisplatin Acute kidney injury Thrombomodulin Tubular cells Mice
Online Access:	https://doi.org/10.1038/s41598-024-64619-y