Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy

Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in silico analysis of drug-protein interaction networks i...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Alina Schidlitzki, Pablo Bascuñana, Prashant K. Srivastava, Lisa Welzel, Friederike Twele, Kathrin Töllner, Christopher Käufer, Birthe Gericke, Rahel Feleke, Martin Meier, Andras Polyak, Tobias L. Ross, Ingo Gerhauser, Jens P. Bankstahl, Michael R. Johnson, Marion Bankstahl, Wolfgang Löscher
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Subjects:	Epileptogenesis Levetiracetam Topiramate Seizures RNA-seq Kainate
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996119303390