Characterization of a PLP-overexpressing transgenic rat, a model for the connatal form of Pelizaeus–Merzbacher disease

Pelizaeus–Merzbacher disease (PMD) most frequently results from duplication of the Plp1 gene with a correlation between disease severity and increasing copy number of the gene. Animal models of PMD, in particular those overexpressing the Plp1 gene, have been sought in attempts to provide systems in...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Joshua A. Mayer, Eric C. Larsen, Yoichi Kondo, Ian D. Duncan
Format:	Article
Language:	English
Published:	Elsevier 2011-11-01
Subjects:	Pelizaeus–Merzbacher disease Proteolipid protein Myelination Plp1 Apoptosis Connatal PMD
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996111002336