Loss of SMAD1 in acute myeloid leukemia with KMT2A::AFF1 and KMT2A::MLLT3 fusion genes

IntroductionKMT2A-rearrangements define a subclass of acute leukemias characterized by a distinct gene expression signature linked to the dysfunctional oncogenic fusion proteins arising from various chromosomal translocations involving the KMT2A (also known as MLL1) gene. Research on the disease pat...

Full description

Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Lisa Dietsche, Kristin Stirm, Veronika Lysenko, Corina Schneidawind, Alexandar Tzankov, Anne Müller, Alexandre P. A. Theocharides
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	KMT2A rearrangement acute myeloid leukaemia SMAD1 TGF-beta signaling KMT2A::AFF1 KMT2A::MLLT3
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1481713/full