Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2

Abstract Background Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch ondrial Stomatin-like protein 2 (SLP-2), which functions in the assembly of respiratory chain proteins, as...

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發表在:	Journal of Translational Medicine
Main Authors:	Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks, Irene Pichler
格式:	Article
語言:	英语
出版:	BMC 2024-01-01
主題:	Parkinson′s disease Parkin SLP-2 Mitochondria Parkin mini-peptide
在線閱讀:	https://doi.org/10.1186/s12967-024-04850-3