Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

ABSTRACT In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system. DNA double-strand breaks (DSB) trigger VSG switching, and repair via gene...

Full description

Bibliographic Details
Published in:mBio
Main Authors: Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Subjects:
Trypanosoma brucei
VSG
antigenic variation
Online Access:https://journals.asm.org/doi/10.1128/mbio.03847-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03847-21

Similar Items