A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells

Abstract Background Nasopharyngeal carcinoma is an aggressive malignancy originating from the nasopharyngeal mucosa and associated with genetic factors. Many nasopharyngeal carcinoma susceptibility loci have been identified by genome-wide association studies (GWASs), but their underlying functional...

Full description

Bibliographic Details

Published in:	Genome Biology
Main Authors:	Tong-Min Wang, Wen-Li Zhang, Jin-Ru Xie, Yong-Qiao He, Minzhong Tang, Wen-Qiong Xue, Da-Wei Yang, Chang-Mi Deng, Hua Diao, Zhi-Ming Mai, Ruo-Wen Xiao, Ying Liao, Dan-Hua Li, Yan-Xia Wu, Cheng-Tao Jiang, Jiang-Bo Zhang, Xue-Yin Chen, Yan Du, Cao-Li Tang, Wen-Hui Jia, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Yonglin Cai, Yuming Zheng, Zhe Zhang, Guangfu Jin, Wen Chen, Hai-Qiang Mai, Ying Sun, Zhibin Hu, Jianjun Liu, Xin-Yuan Guan, Fan Bai, Jinxin Bei, Jun Ma, Musheng Zeng, Maria Li Lung, Hans-Olov Adami, Weimin Ye, Tai-Hing Lam, Hongbing Shen, Wei-Hua Jia
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Online Access:	https://doi.org/10.1186/s13059-025-03657-9