Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T > C mutation

Abstract Background Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p.M64V) mutation caused complex I deficiency, diminished ATP productio...

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Bibliographic Details

Published in:	Journal of Biomedical Science
Main Authors:	Jing Wang, Yanchun Ji, Cheng Ai, Jia-Rong Chen, Dingyi Gan, Juanjuan Zhang, Jun Q. Mo, Min-Xin Guan
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Leber’s hereditary optic neuropathy Mitochondrial DNA mutation Complex I Allotopic expression Apoptosis Mitophagy
Online Access:	https://doi.org/10.1186/s12929-023-00951-1