Failure to Deliver and Translate—New Insights into RNA Dysregulation in ALS

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease affecting both upper and lower motor neurons. The molecular mechanisms underlying disease pathogenesis remain largely unknown. Multiple genetic loci including genes involved in proteostasis and ribostasis have b...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Alyssa N. Coyne, Benjamin L. Zaepfel, Daniela C. Zarnescu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Subjects:	RNA transport stress granules translation TDP-43 FUS C9orf72
Online Access:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00243/full