BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability

Abstract Background Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance genes explain less than 5% of the cases arising at early-onset (< 56 years) and/or with familial aggregation of the disease. Considering that BubR1 is an essen...

Full description

Bibliographic Details

Published in:	Journal of Biomedical Science
Main Authors:	Maria P. Silva, Luísa T. Ferreira, Natércia F. Brás, Lurdes Torres, Andreia Brandão, Manuela Pinheiro, Marta Cardoso, Adriana Resende, Joana Vieira, Carlos Palmeira, Gabriela Martins, Miguel Silva, Carla Pinto, Ana Peixoto, João Silva, Rui Henrique, Sofia Maia, Helder Maiato, Manuel R. Teixeira, Paula Paulo
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	BUB1B BubR1 Cancer predisposition Premature chromatid separation Chromosomal instability Taxol response
Online Access:	https://doi.org/10.1186/s12929-024-01056-z