Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation

Abstract Complex disorders are caused by a combination of genetic, environmental and lifestyle factors, and their prevalence can vary greatly across different populations. The extent to which genetic risk, as identified by Genome Wide Association Study (GWAS), correlates to disease prevalence in dif...

Full description

Bibliographic Details

Published in:	BMC Genomic Data
Main Authors:	Pritesh R. Jain, Myson Burch, Melanie Martinez, Pablo Mir, Jakub P. Fichna, Cezary Zekanowski, Renata Rizzo, Zeynep Tümer, Csaba Barta, Evangelia Yannaki, John Stamatoyannopoulos, Petros Drineas, Peristera Paschou
Format:	Article
Language:	English
Published:	BMC 2023-11-01
Subjects:	GWAS PRS Polygenic risk score Ancestry Disease prevalence
Online Access:	https://doi.org/10.1186/s12863-023-01168-9