Charge-surrounded pockets and electrostatic interactions with small ions modulate the activity of retroviral fusion proteins.

Refolding of viral class-1 membrane fusion proteins from a native state to a trimer-of-hairpins structure promotes entry of viruses into cells. Here we present the structure of the bovine leukaemia virus transmembrane glycoprotein (TM) and identify a group of asparagine residues at the membrane-dist...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Daniel Lamb, Alexander W Schüttelkopf, Daan M F van Aalten, David W Brighty
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-02-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001268&type=printable