Challenges in lentiviral vector production: retro-transduction of producer cell lines

The increasing demand for lentiviral vectors (LVs) has led to the development of several stable cell lines and production methods over the last 2 decades in order to increase titers and yields, reduce production costs and improve the safety of the vector product. However, the phenomenon of retro-tra...

Full description

Bibliographic Details
Published in:Frontiers in Bioengineering and Biotechnology
Main Authors: Maximilian Klimpel, Christin Obert, Monica Terrao, Parameswari Singh, Haiyan Wei, Chao-Guang Chen, Andreas Gille, Silke Wissing, Holger Laux
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Subjects:
lentiviral vector (LV)
viral vector production
retro-transduction
auto-transduction
cell and gene therapy (CGT)
stable producer cell line
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1569298/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2025.1569298/full

Similar Items