A Targeted Integration-Based CHO Cell Platform for Simultaneous Antibody Display and Secretion

Objective: We developed a targeted integration-based CHO cell platform for simultaneous antibody display and secretion, enabling a streamlined transition from antibody library screening to production without requiring the re-cloning of antibody genes. Methods: The platform consists of a CHO master c...

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Bibliographic Details

Published in:	Antibodies
Main Authors:	Jessica P. Z. Ng, Mariati Mariati, Jiawu Bi, Matthew Wook Chang, Yuansheng Yang
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Subjects:	CHO cells antibodies recombinase-mediated cassette exchange manufacturability functionality simultaneous display and secretion
Online Access:	https://www.mdpi.com/2073-4468/14/2/38