In silico analysis of the wild-type and mutant-type of BRCA2 gene

Abstract Background The aim of this study was to conduct an in silico analysis of a novel compound heterozygous variant in breast cancer susceptibility gene 2 (BRCA2) to clarify its structure–function relationship and elucidate the molecular mechanisms underlying triple-negative breast cancer (TNBC)...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Jingjing Li, Rui Ge, Guanming Lu, Yuanxuan Cai, Yuan Teng, Zhe Fan, Liangyan Liao, Lingjie Kong, Jinze Zhang, Tao Wei, Qian Li, Tianzhu Long, Hongyan Yu, Jie Li
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	TNBC BRCA2 Compound heterozygous variants In silico snalysis DNA repair
Online Access:	https://doi.org/10.1186/s12967-024-05200-z