Altered brain expression and cerebrospinal fluid levels of TIMP4 in cerebral amyloid angiopathy

Abstract Cerebral amyloid angiopathy (CAA) is a highly prevalent and progressive pathology, involving amyloid-β (Aβ) deposition in the cerebral blood vessel walls. CAA is associated with an increased risk for intracerebral hemorrhages (ICH). Insight into the molecular mechanisms associated with CAA...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Lieke Jäkel, Anna M. De Kort, Arno Stellingwerf, Carla Hernández Utrilla, Iris Kersten, Marc Vervuurt, Yannick Vermeiren, Benno Küsters, Floris H. B. M. Schreuder, Catharina J. M. Klijn, H. Bea Kuiperij, Marcel M. Verbeek
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	Biomarker Cerebral amyloid angiopathy Intracerebral hemorrhage Tissue inhibitor of metalloproteinases 4
Online Access:	https://doi.org/10.1186/s40478-024-01823-x